Center for Bio-Image Informatics

Engineering, Biology and Computer Science, working together.

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Biological Research - Microtubules

Retina Research

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 The Retinal Research Group studies cellular changes that occur following retinal detachment and reattachment. They are also developing new therapies for the treatment of retinal detachment. In this process, they are generating thousands of high quality images of tissue samples in the form of electron micrographs and laser scanning confocal images.

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Microtubules Dynamics Collection

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The microtubule (MT) image data collection primarily comes from the labs of Leslie Wilson and Stuart Feinstein at UCSB, also from the NRI. Our largest image data set depicts the rapid lengthening and shortening behaviors of MTs, in cells, in a critical process termed microtubule dynamics. The aim of our MT-based studies is to investigate the effects on MT dynamics of endogenous regulators such as the microtubule-associated protein (MAP) tau – implicated in neurodegenerative diseases such as Alzheimer’s disease and dementias- and to further the development of potential anti-cancer chemotherapeutics such as the taxane and sulphorophane drug classes, known to augment MT dynamics and disrupt cell division.
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